Medical Weight Loss
Evidence-based weight loss programs using semaglutide, tirzepatide, tesofensine, and lipotropic injections — personalized to your metabolism, guided by bloodwork, and monitored for results.
Why Medical Weight Loss Works When Diets Fail
If you've tried dieting, exercise, and willpower — and the weight keeps coming back — you're not failing. Your biology is working against you.
When you lose weight through calorie restriction alone, your body responds by lowering your metabolic rate, increasing hunger hormones (ghrelin), and decreasing satiety hormones (leptin). This is called metabolic adaptation — your body's survival mechanism fighting to return to its previous weight. It's the reason 80-95% of people who lose weight through dieting alone regain it within 2-5 years.
Medical weight loss medications work differently. They target the hormonal and neurological pathways that control appetite, satiety, and metabolism — addressing the root cause of weight gain rather than just the symptoms. Combined with lifestyle modifications and medical monitoring, they produce sustainable results that dieting alone cannot achieve.
At Rewind Anti-Aging of Miami, we offer four distinct medication pathways — each with different mechanisms, benefits, and profiles — so your treatment matches your specific physiology and goals.
GLP-1 Receptor Agonists: The Science Behind the Results
GLP-1 (glucagon-like peptide-1) receptor agonists are the most significant advancement in weight loss medicine in decades. Originally developed for Type 2 diabetes, these medications were found to produce dramatic weight loss by mimicking a natural gut hormone that regulates appetite and blood sugar. They work through multiple mechanisms simultaneously:
Appetite Suppression
Activate satiety centers in the brain (hypothalamus), reducing hunger and food cravings
Delayed Gastric Emptying
Slow the rate at which food leaves the stomach, helping you feel full longer after meals
Improved Insulin Sensitivity
Enhance your body's ability to process glucose and reduce fat storage
Reduced Reward-Driven Eating
Decrease the neurological "reward" response to high-calorie foods, making it easier to make better choices
GLP-1 Treatment Options
Three proven medications, each with unique advantages. Your provider will recommend the best fit for your goals and health profile.
Semaglutide (Ozempic / Wegovy)
GLP-1 Receptor AgonistSemaglutide is a GLP-1 receptor agonist administered as a once-weekly subcutaneous injection. It is FDA-approved for chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related comorbidity.
Clinical evidence: The landmark STEP 1 trial, published in the New England Journal of Medicine (2021), demonstrated that participants receiving semaglutide 2.4mg weekly lost an average of 14.9% of their body weight (approximately 33.7 pounds) over 68 weeks, compared to 2.4% in the placebo group. Nearly one-third of participants lost more than 20% of their body weight.
Dosing protocol: Semaglutide follows a gradual dose titration schedule to minimize gastrointestinal side effects. Treatment typically starts at 0.25mg weekly, increasing every 4 weeks through 0.5mg, 1.0mg, 1.7mg, and ultimately 2.4mg. This slow escalation allows your body to adjust and significantly reduces nausea and other GI symptoms.
Tirzepatide (Mounjaro / Zepbound)
Dual GLP-1/GIP Receptor AgonistTirzepatide represents the next evolution in weight loss pharmacology. Unlike semaglutide, which activates only GLP-1 receptors, tirzepatide is a dual GLP-1/GIP receptor agonist — it activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously. This dual mechanism produces significantly greater weight loss than GLP-1 alone.
Clinical evidence: The SURMOUNT-1 trial, published in the New England Journal of Medicine (2022), showed that participants receiving tirzepatide at the highest dose (15mg) lost an average of 22.5% of their body weight over 72 weeks — roughly 52 pounds. More than one-third of participants achieved weight loss of 25% or more, approaching the results of bariatric surgery without any surgical procedure.
Dosing protocol: Tirzepatide starts at 2.5mg weekly, titrating up every 4 weeks through 5mg, 7.5mg, 10mg, 12.5mg, and up to 15mg. As with semaglutide, the gradual increase minimizes side effects while progressively enhancing weight loss.
Retatrutide
Triple GLP-1/GIP/Glucagon Receptor AgonistTriple-agonist peptide targeting GLP-1, GIP, and glucagon receptors for up to 24% body weight reduction.
Clinical evidence: Phase II clinical trial data presented at the American Diabetes Association (2023) showed participants receiving retatrutide at the highest dose achieved up to 24.2% body weight reduction over 48 weeks — the largest weight loss seen with any anti-obesity medication to date.
Dosing protocol: Administered as a once-weekly subcutaneous injection with gradual dose titration. Your provider will determine the appropriate dosing schedule based on your response and tolerability.
All three medications are highly effective. The choice between them depends on your weight loss goals, health history, insurance coverage, and how your body responds. Read our detailed comparison of the difference between tirzepatide and semaglutide. Our medical team will recommend the best option during your consultation and can adjust if needed.
Benefits of Medical Weight Loss
When you lose weight through a medically supervised program, the benefits extend far beyond the number on the scale.
Significant Weight Loss
Clinical trials show 15-22% body weight loss with GLP-1 medications — far beyond what diet and exercise alone can achieve for most people.
Improved Cardiovascular Health
Weight loss reduces blood pressure, cholesterol, and cardiovascular risk factors. GLP-1 medications show independent cardiovascular benefits in clinical trials.
Better Metabolic Health
Improved insulin sensitivity, blood sugar regulation, and reduced risk of Type 2 diabetes.
More Energy & Vitality
Patients consistently report increased energy, better sleep, and improved overall quality of life as excess weight comes off.
Reduced Joint Pain
Less weight means less stress on joints. Many patients see dramatic improvement in knee, hip, and back pain.
Mental Clarity & Confidence
Improved mood, self-esteem, and mental sharpness. The psychological benefits of sustainable weight loss are profound.
Patient Transformations
Watch real Rewind patients share their weight loss journeys and results.
A dramatic change in body fat percentage — a real Rewind patient result.
The impact of Tirzepatide on a real patient's body composition.
Tesofensine: A Different Approach
Tesofensine works through an entirely different mechanism than GLP-1 medications. It is a triple monoamine reuptake inhibitor that blocks the reabsorption of three key neurotransmitters in the brain.
Unlike GLP-1 medications that primarily work through appetite suppression and gastric slowing, tesofensine simultaneously reduces appetite and increases the number of calories your body burns at rest — attacking weight loss from both sides.
Dopamine
Reduces reward-driven eating and food cravings
Serotonin
Enhances mood and reduces emotional eating
Noradrenaline
Increases metabolic rate and energy expenditure
Clinical evidence: A Phase II clinical trial published in The Lancet (2008) showed that tesofensine produced dose-dependent weight loss of up to 10.6% of body weight over 24 weeks — more than twice the weight loss observed with existing anti-obesity drugs at that time.
Important transparency: Tesofensine is not FDA-approved for weight loss in the United States. It is available through compounding pharmacies and prescribed off-label based on clinical trial data. We believe in being completely transparent about the regulatory status of every treatment we offer. Our medical team will discuss the evidence, benefits, and limitations so you can make a fully informed decision.
Semaglutide vs. Tirzepatide
There is no single "best" medication. The right choice depends on your health profile, goals, and how your body responds.
| Factor | Semaglutide | Tirzepatide |
|---|---|---|
| Mechanism | GLP-1 agonist | Dual GLP-1/GIP agonist |
| Avg. Weight Loss | ~15% body weight | ~22.5% body weight |
| Administration | Weekly injection | Weekly injection |
| FDA Approved | Yes (Wegovy) | Yes (Zepbound) |
| Titration Period | 16-20 weeks | 20-24 weeks |
| GI Side Effects | Common, typically mild | Common, typically mild |
| Best For | Moderate weight loss goals, proven track record | Maximum weight loss, patients who haven't responded to semaglutide |
Lipotropic Injections: Supporting Fat Metabolism
Lipotropic injections — often called MIC injections — contain a combination of amino acids and vitamins that support your body's natural fat metabolism processes. They are commonly used as a complement to GLP-1 medications or as a standalone option for patients seeking a lighter-touch approach. Typically administered 1-2 times per week with minimal side effects.
Methionine
An essential amino acid that helps break down fats in the liver and prevents fat accumulation
Inositol
Supports the transport and metabolism of fats, helps regulate insulin, and supports mood
Choline
Essential for fat transport and metabolism, supports liver function and prevents fatty liver
Vitamin B12
Critical for energy production, red blood cell formation, and neurological function. Many patients experience increased energy and mental clarity
What to Expect at Rewind
From consultation to goal weight — every step is data-driven and personalized to you.
Initial Consultation
Discuss your goals, health history, and previous weight loss attempts. We listen first.
Comprehensive Blood Panel
Metabolic markers, hormones (testosterone, thyroid, insulin), liver function, lipids, and more.
Results Review & Treatment Plan
Your provider reviews your labs, recommends a medication pathway, and designs your personalized protocol.
Begin Treatment
Start at the lowest dose with clear instructions on administration, diet, and exercise.
Monthly Follow-Ups
Track progress, adjust dosing, address side effects, and provide ongoing support.
Maintenance Phase
As you approach your goal weight, we develop a long-term plan for sustaining your results.
Combination Therapy: Why It Works Best
Weight gain is rarely caused by a single factor — and the most effective treatment addresses multiple contributors simultaneously. Many of our patients achieve their best results through a combination approach:
- GLP-1 Medication + Hormone Optimization — Balanced testosterone and thyroid hormones directly impact metabolic rate, energy, and body composition. Patients on hormone therapy alongside weight loss medication often see faster, more sustainable results. Learn more
- GLP-1 Medication + Lipotropic Injections — Adding MIC/B12 injections supports liver function and fat metabolism while boosting energy during the calorie deficit.
- Medication + Peptide Therapy — Growth hormone-releasing peptides like sermorelin can improve body composition by supporting lean muscle mass while losing fat. Learn more
Your treatment plan is never one-size-fits-all. Our medical team evaluates your full metabolic picture — hormones, bloodwork, body composition, lifestyle — and designs an integrated protocol targeting every factor contributing to your weight.
Side Effects, Safety, and Contraindications
We believe informed patients make better decisions. Here's what you should know about the safety profile of each medication we prescribe.
GLP-1 Medications (Semaglutide & Tirzepatide)
Common side effects (typically mild, improve with dose titration):
- Nausea (most common, usually resolves within 4-8 weeks)
- Diarrhea or constipation
- Decreased appetite (therapeutic effect, not a side effect per se)
- Abdominal discomfort
- Fatigue during initial titration
Serious but rare risks:
- Pancreatitis — seek immediate medical attention for severe, persistent abdominal pain
- Gallbladder issues — increased risk of gallstones with rapid weight loss
- Thyroid C-cell tumors — observed in animal studies; GLP-1 medications carry a boxed warning and are contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN 2 syndrome
Contraindications: Personal or family history of medullary thyroid carcinoma, MEN 2 syndrome, history of pancreatitis, severe gastrointestinal disease, pregnancy or breastfeeding.
Tesofensine
Common side effects:
- Dry mouth
- Insomnia
- Increased heart rate
- Constipation
- Headache
Contraindications: Uncontrolled hypertension, history of cardiovascular disease, concurrent use of MAO inhibitors, history of stroke or transient ischemic attack.
Lipotropic Injections
Lipotropic injections are generally very well tolerated. Mild injection site discomfort is the most common side effect. Allergic reactions are rare. They are not recommended for patients with B12 sensitivity or certain liver conditions.
Who Is a Candidate for Medical Weight Loss?
Medical weight loss may be right for you if:
- You have a BMI of 30 or greater (obesity)
- You have a BMI of 27 or greater with weight-related health conditions (diabetes, hypertension, sleep apnea, high cholesterol)
- You've tried diet and exercise without lasting success
- You're experiencing symptoms of hormonal imbalance that may be contributing to weight gain
- You want a medically supervised, evidence-based approach rather than fad diets or supplements
During your consultation, our medical team reviews your health history, current medications, and comprehensive bloodwork to determine which medication — if any — is safe and appropriate for you. Not every patient needs medication, and we'll be honest if lifestyle modifications alone are the right starting point.
Why Patients Choose Rewind for Weight Loss
We're not a weight loss factory. We're a boutique medical practice that treats weight loss as the metabolic, hormonal, and behavioral challenge it actually is.
The Broadest Medication Options in Miami
Semaglutide, tirzepatide, tesofensine, and lipotropic injections. Most clinics offer one or two options. We offer all four so your treatment matches your physiology, not our inventory.
Integrated Approach
Weight loss doesn't happen in isolation. We address hormones, metabolism, nutrition, and body composition as interconnected systems.
Honest Transparency
We discuss side effects, contraindications, FDA status, and realistic timelines. No miracle promises.
Data-Driven Protocols
Every treatment decision is informed by your bloodwork, not guesswork.
Ongoing Support
Monthly follow-ups, dose adjustments, and a maintenance plan designed to sustain your results long-term.
Life After Goal Weight: Maintenance
Reaching your goal weight is the beginning, not the end. The most important phase of any weight loss program is what happens after. Our maintenance strategy includes:
We don't stop medication abruptly. For GLP-1 medications, we taper the dose over weeks to months, allowing your body to adjust.
Continued bloodwork to ensure your metabolism, hormones, and metabolic markers remain optimized.
Transition from a weight-loss diet to a sustainable maintenance diet with appropriate caloric targets.
Ensuring testosterone, thyroid, and other hormones support a healthy metabolic rate long-term.
If weight begins to regain, we address it immediately rather than waiting for a full rebound.
Weight Loss Insights from Our Blog
Tirzepatide vs Semaglutide
Comparing the two most popular GLP-1 weight loss medications.
Is Semaglutide the Same as Ozempic?
Understanding semaglutide brands and formulations.
How Long Does It Take to Lose Weight on Mounjaro?
Realistic weight loss timelines with tirzepatide therapy.
Best Peptides for Weight Loss
Peptide-based approaches to fat loss and metabolic health.
Intermittent Fasting: Should You Try It?
Dietary strategies that complement medical weight loss.
Frequently Asked Questions
How much weight can I lose with semaglutide?
Clinical trials (STEP 1) showed participants lost an average of 14.9% of their body weight — approximately 33.7 pounds — over 68 weeks. Individual results vary based on dosage, diet, exercise, and metabolic factors.
How much weight can I lose with tirzepatide?
The SURMOUNT-1 trial showed average weight loss of 22.5% of body weight at the highest dose over 72 weeks — significantly more than semaglutide. Many patients lose 40-60+ pounds.
What is the difference between semaglutide and tirzepatide?
Semaglutide activates GLP-1 receptors only, while tirzepatide activates both GLP-1 and GIP receptors (dual agonist). This dual mechanism typically produces greater weight loss. Your provider will recommend the best option based on your health profile and goals.
What are the side effects of GLP-1 medications?
The most common side effects are gastrointestinal — nausea, diarrhea, constipation, and decreased appetite. These are typically mild to moderate and improve after the first 4-8 weeks as your body adjusts during dose titration. Serious but rare side effects include pancreatitis and gallbladder issues.
Is tesofensine FDA-approved?
Tesofensine is not currently FDA-approved for weight loss in the United States. It is available through compounding pharmacies and prescribed off-label based on Phase II clinical trial data showing up to 10% body weight loss in 6 months. We believe in full transparency about the regulatory status of every treatment we offer.
How long do I need to take weight loss injections?
Treatment duration varies by individual and medication. Most patients are on GLP-1 medications for 6-12 months to reach their goal weight, followed by a maintenance phase. We work with you to develop a sustainable long-term plan that may include dose reduction, lifestyle modifications, or transitioning off medication.
Will I gain the weight back when I stop the medication?
Weight regain is possible if medication is stopped abruptly without lifestyle changes in place. That's why our program includes nutritional guidance, exercise planning, and a structured maintenance phase designed to help you sustain your results long-term.
What is the cost of medical weight loss at Rewind?
Pricing varies based on the medication, dosage, and treatment duration. We discuss all costs transparently during your consultation so there are no surprises. Contact us at (305) 922-9622 for current pricing.
Do I need a prescription for semaglutide or tirzepatide?
Yes, both semaglutide and tirzepatide are prescription medications. During your consultation, our medical team evaluates your health history, current medications, and lab work to determine if you are a safe and appropriate candidate.
Can I combine weight loss injections with hormone therapy?
Yes, and many patients see enhanced results when combining GLP-1 medications with hormone optimization. Balanced hormones — particularly testosterone and thyroid — play a significant role in metabolism, energy, and body composition. We design integrated protocols that address multiple factors simultaneously.
How quickly will I see results?
Most patients notice reduced appetite within the first 1-2 weeks. Measurable weight loss typically begins within the first month, with significant results visible by months 2-3. The dose titration schedule means results accelerate as you reach your therapeutic dose.
Do you offer telehealth weight loss consultations?
Yes, we offer telehealth consultations for weight loss patients throughout Florida. You can complete your initial consultation and follow-ups virtually, with lab work done at a facility near you.
Start Your Weight Loss Journey
Schedule a consultation to discuss which weight loss approach is right for your body, your goals, and your lifestyle.
⚕ Medical Disclaimer
The information on this page is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. All treatments at Rewind Anti-Aging of Miami are performed under the supervision of licensed medical professionals. Individual results may vary. Consult your physician before beginning any new treatment protocol.
Meet our clinical team →Areas We Serve in Miami & South Florida
Our Wynwood clinic at 24 NW 29th Street serves patients across the Miami metro in person and the entire state of Florida via telehealth.