Semaglutide Weight Loss Therapy
Clinically proven GLP-1 receptor agonist therapy supervised by the medical team at Rewind Anti-Aging of Miami. Patients in the landmark STEP trials lost an average of 14.9% of their body weight.
What Is Semaglutide?
Semaglutide is an injectable prescription medication that belongs to a class of drugs known as GLP-1 receptor agonists (glucagon-like peptide-1 receptor agonists). Originally FDA-approved for Type 2 diabetes, researchers observed a remarkable secondary benefit during clinical trials: significant, sustained weight loss.
In June 2021, the FDA approved a higher-dose formulation specifically for chronic weight management in adults with obesity or overweight conditions accompanied by at least one weight-related comorbidity. Today, semaglutide stands as one of the most thoroughly studied and effective pharmaceutical tools available for medically supervised weight loss.
At Rewind Anti-Aging of Miami, we prescribe semaglutide as part of a comprehensive, physician-supervised weight-loss program that combines medication with nutritional guidance, lifestyle coaching, and ongoing monitoring.
How Semaglutide Works: Three Mechanisms
Semaglutide mimics GLP-1, a naturally occurring incretin hormone released by the small intestine after you eat. It amplifies metabolic regulation through three key pathways.
Appetite Suppression
Semaglutide crosses the blood-brain barrier and acts on GLP-1 receptors in the hypothalamus, reducing the neurological drive to eat. This is not willpower — it is a biochemical shift in how your brain perceives hunger.
Delayed Gastric Emptying
Slows the rate at which food leaves the stomach, so you feel full longer after a meal. The slower digestion also blunts post-meal blood sugar spikes, reducing insulin surges that trigger fat storage.
Improved Insulin Sensitivity
Enhances the body's insulin response and suppresses excess glucagon. Your cells become more efficient at using glucose for energy rather than storing it as fat.
Together, these three mechanisms create a powerful, multi-pathway approach to weight reduction that addresses both the behavioral and metabolic drivers of obesity.
Clinical Evidence: The STEP Trials
Semaglutide's efficacy is supported by one of the most robust clinical trial programs in obesity medicine history. Published in the New England Journal of Medicine (February 2021), the STEP 1 trial enrolled 1,961 adults.
Average body weight loss over 68 weeks in the semaglutide group (vs. 2.4% placebo)
Of participants lost 20% or more of their body weight
Reduction in major adverse cardiovascular events in the SELECT trial (2023)
The broader STEP program (STEP 2-5) confirmed findings across diverse populations. The SELECT trial (2023) further demonstrated a 20% reduction in major adverse cardiovascular events, adding a cardioprotective dimension.
A dramatic change in body fat percentage — a real Rewind patient result.
Semaglutide vs. Ozempic vs. Wegovy
One of the most common sources of confusion. Here is a clear breakdown. For a deeper dive, read our guide on whether semaglutide is the same as Ozempic.
Semaglutide
The active pharmaceutical ingredient — the molecule itself. The generic name for the drug compound developed by Novo Nordisk.
Ozempic
Brand-name injectable semaglutide FDA-approved for Type 2 diabetes. Available in doses up to 2.0 mg per week.
Wegovy
Brand-name injectable semaglutide FDA-approved for chronic weight management. Maximum dose of 2.4 mg per week — the formulation used in the STEP trials.
There is also Rybelsus, an oral semaglutide tablet approved for Type 2 diabetes, though not typically used for weight loss due to lower bioavailability. At Rewind Anti-Aging, we work with compounded semaglutide formulations prescribed specifically for weight management.
Dosing and Titration Schedule
Semaglutide is administered as a once-weekly subcutaneous injection. The gradual titration is critical for minimizing side effects.
Initial introduction; body acclimates to GLP-1 activity
First therapeutic increase; appetite changes become noticeable
Continued escalation; significant appetite suppression for most patients
Approaching target dose; weight loss typically accelerates
Full maintenance dose; maximum therapeutic effect achieved
Jumping to higher doses too quickly is the most common cause of GI discomfort. Our team monitors your progress at every step. Some patients achieve their goals at lower doses and never need to reach 2.4 mg.
What to Expect Week by Week
Early Adjustment
Subtle reduction in appetite and food noise. Hunger between meals decreases. You naturally reach for smaller portions. Weight loss of 1-3 pounds.
Building Momentum
Appetite suppression becomes more consistent. You lose interest in snacking and late-night eating. Cumulative weight loss of 3-5 pounds.
Noticeable Changes
After the dose increase to 0.5 mg, feeling full after half your usual portion. Weight loss of 5-10 pounds. Energy levels improve.
Accelerating Results
Clothes begin fitting differently. Total weight loss of 8-15 pounds. Blood sugar and cholesterol panels show measurable improvement.
Reaching Full Dose
Weight loss continues steadily. By week 20, many patients have lost 10-20% of their starting body weight. Relationship with food shifts fundamentally.
Long-Term Maintenance
Weight loss continues gradually and typically plateaus around months 12-16. We focus on locking in results through nutrition and exercise planning.
Side Effects and Safety
Like all prescription medications, semaglutide carries potential side effects. Transparency about risks is core to our process. If you drink, review our guide on Ozempic and alcohol.
Common Side Effects (GI)
These are dose-dependent and typically resolve within 1-2 weeks of each dose adjustment.
- Nausea — Most common, reported by ~44% of patients in trials; worst during first weeks and after dose increases
- Diarrhea — Reported by ~30% of participants
- Constipation — Affects ~24% of patients
- Vomiting — Occurs in ~24% of patients, usually transient
- Abdominal discomfort — Mild cramping or bloating, particularly after meals
Rare but Serious Risks
Our medical team screens for all contraindications before prescribing.
- Pancreatitis: Report severe, persistent abdominal pain immediately
- Gallbladder disease: Rapid weight loss of any kind can increase gallstone risk
- Hypoglycemia: Uncommon when used alone; possible when combined with insulin or sulfonylureas
- Thyroid C-cell tumors (boxed warning): Contraindicated in patients with personal or family history of MTC or MEN 2 syndrome
Who Is a Candidate for Semaglutide?
- BMI of 30 or greater (classified as obesity)
- BMI of 27 or greater with at least one weight-related comorbidity (hypertension, Type 2 diabetes, dyslipidemia, sleep apnea)
- Struggled with yo-yo dieting and repeated weight regain
- Unable to achieve sustainable results through diet and exercise alone
- Seeking a medically supervised, evidence-based approach to weight loss
- Motivated to combine medication with healthy lifestyle changes
Who Should NOT Take Semaglutide
- Personal or family history of medullary thyroid carcinoma (MTC)
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Women who are pregnant, planning to become pregnant, or breastfeeding
- History of severe pancreatitis
- Known hypersensitivity to semaglutide or any product components
Understanding Semaglutide Pricing
The cost of semaglutide therapy varies significantly depending on whether you use brand-name medication or compounded formulations, whether insurance covers your treatment, and what level of medical oversight is included in your program.
At Rewind, pricing is transparent and all-inclusive — medication, provider oversight, metabolic monitoring, and dosage adjustments are bundled with no hidden fees or long-term contracts.
See the Full Cost Breakdown →Related Treatments
Tirzepatide Therapy
Dual GLP-1/GIP receptor agonist with up to 22.5% average weight loss in clinical trials.
Learn more →Tesofensine Therapy
Oral triple reuptake inhibitor that reduces appetite and boosts metabolism through a different pathway.
Learn more →Medical Weight Loss
Comprehensive physician-supervised weight loss programs combining medication, labs, and lifestyle coaching.
Learn more →Explore Semaglutide in Depth
Is Semaglutide the Same as Ozempic?
Understanding the relationship between semaglutide, Ozempic, and Wegovy.
Semaglutide and Hypothyroidism
What you need to know about semaglutide if you have thyroid conditions.
Does Ozempic Lower Cholesterol?
How semaglutide affects cardiovascular markers beyond weight loss.
Ozempic and Alcohol: What You Need to Know
Important guidance on alcohol consumption during semaglutide therapy.
Tirzepatide vs Semaglutide: What's the Difference?
Comparing two leading GLP-1 weight loss medications.
Semaglutide Cost: What You'll Actually Pay
See the full cost breakdown — brand-name vs compounded, insurance vs cash pay, and what's included.
Semaglutide Side Effects: What to Know Before Starting Treatment
Common side effects, how they're managed, and what your provider monitors during treatment.
What Happens When You Stop Taking Semaglutide?
Weight regain risk, transition strategies, and how to maintain your results long-term.
Frequently Asked Questions About Semaglutide
How much weight can I lose on semaglutide?
Clinical trial data from the STEP program showed participants lost an average of 14.9% of their body weight over 68 weeks. Individual results vary based on starting weight, adherence to the dosing schedule, diet, and physical activity. Many patients at Rewind Anti-Aging of Miami begin noticing meaningful weight loss within the first four to six weeks of treatment.
Is semaglutide the same as Ozempic or Wegovy?
Semaglutide is the active pharmaceutical ingredient found in both Ozempic and Wegovy. Ozempic is FDA-approved specifically for Type 2 diabetes management, while Wegovy is approved for chronic weight management. At our Miami clinic, we prescribe compounded semaglutide tailored to your weight-loss goals and medical history.
How long do I need to take semaglutide?
Most patients follow a treatment course of six months to one year, though the optimal duration depends on your individual goals and response to therapy. Our providers at Rewind Anti-Aging of Miami create a personalized timeline during your initial consultation and adjust it as you progress through your weight-loss journey.
What are the most common side effects of semaglutide?
The most frequently reported side effects are gastrointestinal in nature, including nausea, diarrhea, constipation, and occasional vomiting. These symptoms are typically mild, occur early in treatment or after dose increases, and tend to diminish as your body adjusts. Our gradual titration protocol is specifically designed to minimize these effects.
Do I need to follow a special diet while taking semaglutide?
While no single diet is required, we strongly recommend a balanced, nutrient-dense eating plan that emphasizes lean proteins, vegetables, and whole grains. Semaglutide reduces appetite naturally, which makes it easier to maintain a caloric deficit. Our team provides dietary guidance as part of your comprehensive treatment plan.
Will I regain weight after stopping semaglutide?
Research indicates that some weight regain can occur after discontinuation if lifestyle habits are not maintained. That is why our approach at Rewind Anti-Aging of Miami pairs semaglutide therapy with nutrition counseling and sustainable lifestyle modifications to help you maintain your results long after treatment concludes.
Can I take semaglutide if I do not have diabetes?
Yes. While semaglutide was originally developed for Type 2 diabetes, it is FDA-approved under the brand name Wegovy for chronic weight management in adults with a BMI of 30 or greater, or a BMI of 27 or greater with at least one weight-related health condition. You do not need a diabetes diagnosis to qualify.
How do I get started with semaglutide therapy at Rewind Anti-Aging of Miami?
Getting started is straightforward. Call us at (305) 922-9622 or request a consultation through our website. During your initial visit, our medical team will review your health history, check your BMI and lab work, and determine whether semaglutide is the right fit for your weight-loss goals.
Start Your Semaglutide Weight Loss Journey
Semaglutide therapy at Rewind Anti-Aging of Miami is more than a prescription — it is a physician-guided program designed to help you lose weight safely, improve your metabolic health, and build habits that last.
⚕ Medical Disclaimer
The information on this page is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. All treatments at Rewind Anti-Aging of Miami are performed under the supervision of licensed medical professionals. Individual results may vary. Consult your physician before beginning any new treatment protocol.
Meet our clinical team →Areas We Serve in Miami & South Florida
Our Wynwood clinic at 24 NW 29th Street serves patients across the Miami metro in person and the entire state of Florida via telehealth.