Happy couple embracing on a Miami beach — restored intimacy through ED treatment at Rewind
Miami, FL

Erectile Dysfunction Treatment

Comprehensive, evidence-based ED treatment — from custom oral compounds and injectable therapy to hormone optimization and peptide protocols. Multiple treatment pathways, personalized to your situation.

Medically Supervised Data-Driven Treatment Personalized Protocols Ongoing Monitoring

What Is Erectile Dysfunction?

Erectile dysfunction (ED) is the consistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Occasional difficulty with erections is normal and happens to most men. ED becomes a medical concern when it is persistent — occurring in more than 25% of sexual encounters — or when it is progressive, getting worse over time.

ED is not a diagnosis in itself so much as a symptom — often the first visible sign of an underlying condition that deserves attention. Low testosterone is one of the most common hormonal drivers of ED. Understanding the cause of your ED is just as important as treating the symptom, because the underlying cause may have implications for your cardiovascular health, metabolic health, and longevity.

Erectile dysfunction treatment consultation at Rewind Anti-Aging Miami

How Common Is Erectile Dysfunction?

Far more common than most men realize. The Massachusetts Male Aging Study — the most widely cited ED prevalence study — found:

52%

of men ages 40-70 experience some degree of ED

40%

of men affected at age 40

70%

prevalence by age 70

30M

American men have ED

75%

never seek treatment

ED also affects younger men more frequently than commonly believed. Studies suggest that 8-10% of men aged 20-29 and 11-15% of men aged 30-39 experience some degree of erectile difficulty, often driven by performance anxiety, medication side effects (particularly SSRIs), or early metabolic dysfunction.

Causes of Erectile Dysfunction

An erection is a complex vascular, neurological, and hormonal event. Disruption at any point — from brain signaling to blood vessel dilation to smooth muscle relaxation — can produce ED.

Vascular Causes — The Most Common Physical Cause

Atherosclerosis

Plaque buildup reduces blood flow. Penile arteries (1-2mm) clog before coronary arteries (3-4mm) — ED often precedes heart attack or stroke by 3-5 years.

Hypertension

Damages the endothelial lining of blood vessels and reduces nitric oxide availability.

Diabetes

Damages both blood vessels and nerves. Up to 75% of diabetic men experience ED.

High Cholesterol

Contributes to atherosclerosis and endothelial dysfunction.

Obesity

Associated with endothelial dysfunction, low testosterone, and increased inflammatory markers.

Smoking

Damages blood vessel walls and reduces blood flow. Smokers are approximately 50% more likely to develop ED.

Hormonal Causes

Low Testosterone

Reduces libido and impairs nitric oxide synthesis and smooth muscle function. An estimated 25% of men over 30 have clinically low testosterone.

Elevated Estrogen

Excess estradiol (often from aromatization of testosterone in overweight men) can suppress sexual function.

Thyroid Disorders

Both hypothyroidism and hyperthyroidism are associated with ED.

Elevated Prolactin

Can suppress testosterone and sexual function.

Neurological & Structural Causes

  • Spinal cord injury or nerve damage
  • Multiple sclerosis, Parkinson's disease
  • Pelvic surgery (prostatectomy, colorectal surgery)
  • Pelvic radiation therapy
  • Peyronie's disease (scar tissue in the penis)

Psychological Causes

Performance Anxiety

The most common psychological cause, creating a self-reinforcing cycle where fear of failure leads to failure.

Stress

Chronic work or life stress elevates cortisol, which suppresses testosterone and sexual function.

Depression

Both the condition itself and many antidepressant medications (SSRIs, SNRIs) impair erectile function.

Relationship Issues

Conflict, lack of emotional intimacy, and communication breakdown.

Medication-Induced ED

  • Antidepressants (SSRIs like sertraline, paroxetine, fluoxetine)
  • Blood pressure medications (beta-blockers, thiazide diuretics)
  • Finasteride / dutasteride (for hair loss or prostate)
  • Opioid pain medications
  • Antihistamines
  • Benzodiazepines
  • Excessive alcohol

If you suspect a medication is contributing to ED, we can evaluate alternatives or adjunct treatments. Never stop a prescribed medication without consulting your healthcare provider.

ED as an Early Warning Sign for Cardiovascular Disease

This may be the most important information on this page. Erectile dysfunction is not just a quality-of-life issue — it is a vascular health marker. Because the penile arteries are significantly smaller than coronary arteries, atherosclerotic plaque accumulates there first.

ED typically presents 3-5 years before a major cardiovascular event. This means erectile dysfunction can serve as an early warning system — a window of opportunity to identify and treat cardiovascular risk factors before a heart attack or stroke occurs.

At Rewind Anti-Aging, we don't just prescribe an ED medication and send you home. We evaluate the vascular, metabolic, and hormonal factors driving your ED — including lipid panels, fasting insulin, hemoglobin A1c, inflammatory markers, and blood pressure — because treating ED properly means treating the whole patient.

59%

increased risk of cardiovascular disease

74%

increased risk of coronary heart disease

33%

increased risk of stroke

Research published in the European Heart Journal — men with ED compared to men without ED.

Treatment Options at Rewind Anti-Aging

We offer multiple treatment pathways — personalized to your root cause, severity, and goals.

PDE5 Inhibitors & Custom Compounds

First-line oral medications — sildenafil, tadalafil, and our exclusive multi-ingredient sublingual troches combining PDE5 inhibitors with oxytocin, testosterone, and sermorelin.

Injectable Therapy (BiMix, TriMix, QuadMix)

The most effective non-surgical ED treatment — 85-90% efficacy. Medication delivered directly to the penile tissue for firm, reliable erections within 5-15 minutes.

Testosterone Optimization

Low T is often the underlying driver of both ED and low libido. Restoring testosterone to optimal levels frequently resolves ED or makes other treatments work significantly better.

PT-141 (Bremelanotide)

Targets desire at the neurological level by activating melanocortin receptors in the brain. Ideal for men whose ED has a significant desire or psychological component.

Custom Compound Blends

Multi-ingredient sublingual troches that address ED from multiple pathways simultaneously — formulations you will not find at a standard pharmacy.

Sildenafil + Oxytocin

Blood flow enhancement plus arousal, bonding, and anti-anxiety effects.

Sildenafil + Testosterone

PDE5 inhibition plus direct testosterone support for desire and erection quality.

Tadalafil + Testosterone

Long-acting PDE5 inhibitor with hormonal support.

Tadalafil + Oxytocin + Sermorelin + Testosterone

Our most comprehensive compound — blood flow, hormonal support, growth hormone peptide, and neuroendocrine enhancement.

BiMix, TriMix & QuadMix Compared

For men who do not respond adequately to oral medications — the most effective non-surgical ED treatment available.

Injectable Active Ingredients Efficacy Best For
BiMix Papaverine + Phentolamine ~80% Good first-line injectable for men transitioning from oral medications.
TriMix Alprostadil + Papaverine + Phentolamine 85-90% The gold standard. Three compounds act synergistically for firm, reliable erections.
QuadMix Alprostadil + Papaverine + Phentolamine + Atropine ~100% For treatment-resistant cases. The last-resort injectable before considering surgery.
Man experiencing symptoms of low testosterone and erectile dysfunction at Rewind Anti-Aging Miami

Simpler Than You Think

We understand that the idea of penile injection causes anxiety for most men. The reality is far less daunting than the concept:

  • Ultra-fine 29-31 gauge insulin syringes — minimal discomfort
  • Injection into the side of the shaft, avoiding the dorsal nerve and urethra
  • Most men describe a brief pinch lasting about one second
  • We teach the complete technique in our office and supervise your first injection
  • Most patients are comfortable self-injecting within one or two attempts

When to See a Doctor About ED

Many men delay seeking help due to embarrassment. But given what we know about ED as a cardiovascular marker, earlier evaluation is always better.

ED occurs in more than 25% of sexual encounters
ED is getting progressively worse over weeks or months
ED appeared suddenly — may indicate a vascular event, nerve injury, or psychological trigger
Accompanied by other symptoms — fatigue, weight gain, mood changes, or reduced morning erections
Causing relationship distress or significantly reducing quality of life
You have cardiovascular risk factors — diabetes, hypertension, high cholesterol, smoking, or family history
How It Works

Our Approach to ED Treatment

From consultation to optimization — every step is data-driven and personalized to you.

Step 01

Confidential Consultation

We discuss your sexual health history, symptom onset and pattern, medical history, medications, lifestyle factors, and goals in a private, judgment-free setting.

Step 02

Comprehensive Blood Panel

Total and free testosterone, estradiol, SHBG, PSA, thyroid panel, CBC, CMP, lipid panel, fasting insulin, hemoglobin A1c, and inflammatory markers.

Step 03

Root-Cause Identification

Is it vascular, hormonal, psychological, medication-related, or a combination? The answer determines the right treatment approach.

Step 04

Personalized Treatment Plan

We match the treatment to your specific situation — starting with the least invasive effective option and escalating only as needed.

Step 05

Follow-Up & Optimization

ED treatment requires fine-tuning. We follow up to assess results, adjust medications and dosing, and ensure you are getting the outcomes you want.

Why Men Choose Rewind for ED Treatment

Multiple Treatment Pathways

Oral medications, custom compounds, BiMix, TriMix, QuadMix, testosterone therapy, PT-141. We match the treatment to you.

Custom Compounding

Our blended sublingual troches (sildenafil + oxytocin + testosterone, etc.) are tailored formulations you will not find at a standard pharmacy.

Root-Cause Approach

We investigate the hormonal, vascular, and metabolic factors behind your ED and address them — not just prescribe a pill.

ED as a Health Indicator

We evaluate cardiovascular risk factors alongside ED because treating your erection without addressing your heart health is incomplete medicine.

Complete Confidentiality

HIPAA-compliant, private consultations, discreet treatment. We understand the sensitive nature of these concerns.

Integrated with Overall Health

ED treatment at Rewind connects to our broader hormone optimization, metabolic health, and wellness programs.

Frequently Asked Questions

How common is erectile dysfunction?

Extremely common. The Massachusetts Male Aging Study found that 52% of men between ages 40 and 70 experience some degree of ED. Approximately 40% of men are affected at age 40, and that number climbs to nearly 70% by age 70. An estimated 30 million American men have ED, yet only about 25% seek treatment — meaning roughly 22 million men are living with untreated erectile dysfunction. ED is not a normal part of aging. It is a treatable medical condition.

Is erectile dysfunction a sign of heart disease?

It can be, and this is critically important. The penile arteries are smaller than coronary arteries, so they develop plaque buildup earlier. ED frequently precedes a cardiovascular event by 3-5 years. A 2018 meta-analysis in the European Heart Journal found that men with ED have a 59% higher risk of cardiovascular disease, a 74% higher risk of coronary heart disease, and a 33% higher risk of stroke compared to men without ED. If you develop ED — especially without an obvious psychological cause — it should prompt a cardiovascular evaluation, not just an ED prescription.

What is the difference between Viagra, Cialis, and your custom compounds?

Viagra (sildenafil) works within 30-60 minutes and lasts 4-6 hours — best for on-demand use. Cialis (tadalafil) works within 30-60 minutes but lasts up to 36 hours, and can also be taken daily at a low dose for continuous readiness. Our custom compound blends go beyond single-ingredient medications. We offer sildenafil or tadalafil combined with oxytocin (for arousal and bonding), testosterone (for direct hormonal support), and even sermorelin (a growth hormone peptide) — delivered as sublingual troches for faster absorption. These multi-ingredient blends address ED from multiple pathways simultaneously.

What is TriMix and how effective is it?

TriMix is an injectable medication containing three active ingredients: alprostadil (a prostaglandin), papaverine (a vasodilator), and phentolamine (an alpha-blocker). These work synergistically to increase arterial blood flow, relax smooth muscle, and restrict venous outflow — producing a firm, reliable erection within 5-15 minutes of injection. TriMix is approximately 85-90% effective, including in men who do not respond to oral medications like Viagra or Cialis. It is considered the gold standard in injectable ED therapy.

Does the injection hurt?

Much less than you'd expect. We use ultra-fine 29-31 gauge insulin syringes — the same needles used for diabetic insulin injections. Most men describe a brief pinch that lasts about one second. The injection is self-administered into the side of the penile shaft (the corpus cavernosum), avoiding the top and bottom where nerves and the urethra are located. We teach you the technique in the office, and most patients are comfortable self-injecting within their first or second attempt.

Can low testosterone cause erectile dysfunction?

Yes. Testosterone is essential for sexual desire (libido) and also plays a direct role in the physiological mechanisms of erection — it supports nitric oxide synthesis and smooth muscle function in the penis. Men with low testosterone often experience both reduced desire and reduced erectile function. Restoring testosterone to optimal levels through hormone replacement therapy frequently improves or resolves ED without the need for additional medications. For men who still need PDE5 inhibitors or injectables, optimized testosterone makes those treatments work significantly better.

What is PT-141 and who is it for?

PT-141 (bremelanotide) is a peptide that works through the central nervous system — specifically melanocortin receptors in the brain — to increase sexual desire and arousal. Unlike Viagra and Cialis, which work on blood flow mechanics, PT-141 addresses the neurological component of sexual function. It is particularly useful for men whose ED has a significant psychological or desire-related component, or who want to combine enhanced desire with enhanced mechanics. PT-141 is administered as a subcutaneous injection 45-60 minutes before sexual activity.

When should I see a doctor about ED?

You should seek evaluation if ED occurs in more than 25% of sexual encounters, if it is progressing in frequency or severity, if it appeared suddenly (which may indicate a vascular or neurological event), if it is accompanied by other symptoms like fatigue or mood changes (suggesting low testosterone), or if it is causing relationship distress or reduced quality of life. Because ED can be an early warning sign of cardiovascular disease, diabetes, or hormonal disorders, getting evaluated serves your overall health — not just your sexual health.

Take the First Step

Erectile dysfunction is a treatable medical condition — not something you have to accept. Schedule a confidential consultation to discuss your options and get a comprehensive evaluation.

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Medical Director: Dr. Jeffrey C. Lombardo, M.D. Reviewed by Alexia Padron, MSN, APRN, FNP-BC Last reviewed: April 2026

Medical Disclaimer

The information on this page is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. All treatments at Rewind Anti-Aging of Miami are performed under the supervision of licensed medical professionals. Individual results may vary. Consult your physician before beginning any new treatment protocol.

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Areas We Serve in Miami & South Florida

Our Wynwood clinic at 24 NW 29th Street serves patients across the Miami metro in person and the entire state of Florida via telehealth.

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