TrueAge Epigenetic Diagnostic Test
Your birth certificate says one age. Your cells may tell a very different story. The TrueAge test measures your biological age at the molecular level — and gives you a concrete number to track as you work to reverse the clock.
Chronological vs. Biological Age
Your chronological age is simply how many years you've been alive. It's fixed, immutable, and tells you almost nothing about how your body is actually aging. Two 50-year-olds can have vastly different biological ages — one might have the cellular health of a 42-year-old, while the other's cells look closer to 60.
The difference comes down to genetics, lifestyle, stress, sleep quality, nutrition, exercise, environmental exposures, and — critically — the interventions you choose. Biological age is modifiable. You can measure it, and you can change it. Therapies like peptide therapy are among the tools that can address the biological aging process.
Understanding Biological Age
The most important number in anti-aging medicine is one most people have never heard of.
What It Is
Biological age measures how old your cells actually are based on DNA methylation patterns — chemical markers that change predictably as your body ages. It reflects the cumulative impact of your genetics, lifestyle, environment, and health choices.
Why It Matters
Biological age is a stronger predictor of disease risk, healthspan, and mortality than chronological age. Someone biologically older than their years faces higher risk of chronic disease, cognitive decline, and reduced lifespan — regardless of how old they actually are.
It's Modifiable
Unlike chronological age, biological age can be reversed. Research demonstrates that hormone optimization, exercise, nutrition, stress management, and targeted supplementation can reduce biological age by 1-3 years in as little as 8-12 months.
DNA Methylation and Epigenetic Clocks
DNA methylation is a process where methyl groups (chemical tags) are added to specific locations on your DNA. These tags don't change your genetic code — they change how your genes are expressed. As you age, methylation patterns change in predictable ways across hundreds of thousands of sites in your genome.
Scientists have mapped these age-related methylation changes and built epigenetic clocks — algorithms that calculate biological age based on methylation patterns. The TrueAge test uses multiple validated clocks for the most comprehensive analysis available.
Horvath Clock
The original multi-tissue epigenetic clock. Analyzes 353 CpG sites and works across virtually all human tissues and cell types.
Hannum Clock
Blood-based epigenetic clock using 71 CpG sites. Optimized for blood samples and validated in large population studies.
PhenoAge
Second-generation clock trained on clinical biomarkers and mortality data. Predicts healthspan and disease risk, not just chronological age.
GrimAge
The most predictive clock for mortality and morbidity. Incorporates smoking pack-years, plasma protein levels, and other health indicators.
What TrueAge Measures
The TrueAge test analyzes approximately 900,000 DNA methylation sites from a blood sample. This isn't a consumer-grade saliva test — it uses clinical-grade Illumina methylation array technology, the same platform used in peer-reviewed aging research.
Biological Age
Your overall biological age calculated across multiple validated epigenetic clocks — the single most important number in aging science.
Age Acceleration
How many years older or younger you are compared to your chronological age. Negative numbers mean you are aging slower than expected.
Rate of Aging
Whether you are aging faster, slower, or at the expected rate — expressed as years of biological aging per calendar year.
Immune Age
The biological age of your immune system (immunosenescence) — a key predictor of disease susceptibility and vaccine response.
Telomere Estimation
An additional aging biomarker derived from methylation data — telomere shortening is associated with cellular aging and disease risk.
Why This Matters for Anti-Aging
Without TrueAge, anti-aging treatment is largely subjective. You might feel better on hormone therapy or peptides, but how do you know it's actually slowing or reversing aging at the cellular level?
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Objective Baseline
Know your true biological age before starting any intervention. This is your starting point — the number everything gets measured against.
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Treatment Validation
Retest at 6-12 months to prove whether HRT, peptides, lifestyle changes, or other protocols are measurably reducing biological age.
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Protocol Optimization
If biological age isn't improving, we know to adjust the approach. Data replaces guesswork.
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Motivation
Seeing your biological age decrease by 2-3 years is a powerful motivator to maintain healthy habits and continue your anti-aging program.
What Affects Your Biological Age
Your biological age is not fixed. These are the factors that push it in either direction.
Factors That Accelerate Aging
- Chronic stress and elevated cortisol
- Poor sleep quality and duration
- Sedentary lifestyle
- Processed food and high sugar intake
- Hormonal decline (low testosterone, estrogen, thyroid)
- Chronic inflammation
- Environmental toxin exposure
- Excessive alcohol consumption
- Smoking
Factors That Reverse Aging
- Hormone optimization (TRT, HRT, thyroid)
- Regular exercise — both resistance training and cardiovascular
- Quality sleep (7-9 hours, consistent schedule)
- Whole-food, nutrient-dense diet
- Stress management and cortisol regulation
- Peptide therapy (growth hormone secretagogues)
- Targeted supplementation (vitamin D, omega-3, NAD+ precursors)
- Caloric optimization and metabolic health
What to Expect
From blood draw to actionable insights — a simple, straightforward process.
Blood Draw
A standard venous blood sample collected at our Wynwood clinic. Quick, simple, and no special preparation required.
Lab Processing
Your sample is analyzed using clinical-grade Illumina methylation array technology — the same platform used in peer-reviewed aging research.
Comprehensive Report
You receive a detailed report with your biological age, rate of aging, immune age, telomere estimation, and personalized recommendations.
Results Consultation
We review your results in detail and discuss how they inform your anti-aging treatment plan — whether it is HRT, peptides, lifestyle, or all of the above.
Your TrueAge Test Includes
Every TrueAge test comes with a comprehensive analysis and personalized consultation.
Epigenetic Biological Age
Multi-clock analysis using Horvath, Hannum, PhenoAge, and GrimAge algorithms for the most comprehensive biological age assessment available.
Extrinsic Epigenetic Age
Measures how environmental factors and lifestyle choices are impacting your aging trajectory, independent of intrinsic biological processes.
Weight Loss Response
Epigenetic markers that predict how your body responds to caloric restriction, exercise, and metabolic interventions for weight management.
2-3 Week Turnaround
Results are typically available within 2-3 weeks of your blood draw. We schedule your results consultation as soon as your report is ready.
Learn From the Experts
In-depth video explanations from leading researchers in epigenetic testing and biological aging.
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What Is Peptide Therapy?
How peptide therapy can address the biological aging process.
Vitamin D and Testosterone
The role of key biomarkers in healthy aging.
TrueAge Epigenetic Testing: What Your Biological Age Reveals
How DNA methylation testing measures your true biological age — and what you can do about it.
Frequently Asked Questions
What is biological age?
Biological age measures how old your cells actually are based on molecular markers — specifically DNA methylation patterns. Unlike chronological age (how many birthdays you've had), biological age reflects how your lifestyle, environment, stress, diet, exercise, and genetics have actually impacted your body's aging process. Someone chronologically 50 could have a biological age of 42 or 58.
How does the TrueAge test work?
TrueAge analyzes approximately 900,000 DNA methylation sites from a blood sample. These methylation patterns — chemical tags on your DNA that regulate gene expression — change predictably with aging. By comparing your methylation profile against validated aging algorithms, the test calculates your biological age with high precision.
How accurate is the TrueAge test?
TrueAge uses multiple validated epigenetic clocks including Horvath, Hannum, PhenoAge, and GrimAge algorithms. These clocks have been validated in large population studies and are considered the gold standard for biological age measurement. The test provides a comprehensive multi-clock analysis rather than relying on a single algorithm.
Can I actually reverse my biological age?
Yes — research has demonstrated that biological age can be reduced through lifestyle interventions, hormone optimization, exercise, diet, stress management, and targeted supplementation. Studies have shown reductions of 1-3 years in biological age over 8-12 months with comprehensive interventions. The TrueAge test lets you objectively measure whether your anti-aging protocols are working.
How often should I get tested?
We recommend a baseline test before starting any anti-aging program, then a follow-up at 6-12 months to measure the impact of your interventions. Annual testing thereafter provides ongoing tracking of your aging trajectory.
Is the TrueAge test covered by insurance?
The TrueAge test is not covered by insurance. It is considered an elective wellness test. We can discuss current pricing during your consultation.
How Old Are Your Cells?
Get your biological age baseline. Then let's work together to reverse it.
⚕ Medical Disclaimer
The information on this page is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. All treatments at Rewind Anti-Aging of Miami are performed under the supervision of licensed medical professionals. Individual results may vary. Consult your physician before beginning any new treatment protocol.
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Our Wynwood clinic at 24 NW 29th Street serves patients across the Miami metro in person and the entire state of Florida via telehealth.