NAD+ IV Therapy in Miami, FL

What Is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every living cell in your body. It is not a vitamin, a mineral, or a drug — it is a fundamental molecule that your cells require to perform hundreds of metabolic reactions essential for life. Without adequate NAD+, your cells cannot produce energy efficiently, repair damaged DNA, regulate inflammation, or communicate effectively with one another.

NAD+ exists in two forms: NAD+ (the oxidized, active form) and NADH (the reduced form). These two forms shuttle electrons between metabolic reactions, acting as a critical intermediary in the conversion of nutrients into cellular energy (ATP). Beyond energy production, NAD+ activates key enzyme families — including sirtuins and poly-ADP-ribose polymerases (PARPs) — that govern DNA repair, gene expression, cellular stress response, and longevity pathways.

In recent years, NAD+ has become one of the most studied molecules in longevity science. Researchers have identified declining NAD+ levels as a hallmark of aging — and restoring NAD+ as a potential strategy for slowing or partially reversing age-related cellular decline.

Why NAD+ Declines with Age

NAD+ levels peak in youth and decline steadily with age. By age 60, most adults have approximately 50% less NAD+ than they had in their 20s and 30s. This decline is driven by several converging factors:

• Increased CD38 activity — CD38 is an enzyme expressed by immune cells that consumes NAD+ as part of the inflammatory response. As chronic, low-grade inflammation (inflammaging) increases with age, CD38 activity rises, consuming more and more NAD+.
• Increased DNA damage — accumulated oxidative stress, environmental toxins, and cellular wear-and-tear produce DNA damage that requires NAD+-dependent repair enzymes (PARPs) to fix. More damage means more NAD+ consumed for repair.
• Decreased biosynthesis — the body's ability to synthesize NAD+ from precursors (tryptophan, nicotinamide, nicotinic acid) diminishes with age due to reduced enzyme efficiency.
• Chronic inflammation — inflammation both consumes NAD+ directly and upregulates the enzymes that degrade it, creating a vicious cycle of depletion.

The consequence of declining NAD+ is a progressive reduction in your cells' ability to produce energy, repair themselves, and resist stress — which manifests as the fatigue, cognitive decline, reduced resilience, and accelerated aging that most people experience as they get older.

What NAD+ Does in Your Body

Energy and ATP Production

NAD+ is essential for mitochondrial function — the process by which your cells convert nutrients into adenosine triphosphate (ATP), the universal energy currency of the cell. NAD+ participates directly in the citric acid cycle and the electron transport chain, the metabolic pathways that generate the vast majority of your cellular energy. When NAD+ is depleted, mitochondrial efficiency drops, and your cells produce less energy — resulting in the fatigue, reduced stamina, and slower recovery that characterize aging.

DNA Repair via Sirtuins and PARPs

Sirtuins are a family of seven enzymes (SIRT1-SIRT7) that regulate DNA repair, gene expression, inflammation, and cellular stress response. They are often called "longevity genes" because of their role in promoting cellular resilience and lifespan extension in multiple organisms. Sirtuins are entirely dependent on NAD+ — they cannot function without it.

PARPs (poly-ADP-ribose polymerases) are DNA repair enzymes that detect and fix DNA strand breaks. They consume NAD+ as fuel for the repair process. When NAD+ is insufficient, DNA damage accumulates, contributing to cellular dysfunction, mutations, and accelerated aging.

Cellular Communication

NAD+ plays a role in cell signaling pathways that coordinate responses to stress, regulate circadian rhythm, and maintain metabolic homeostasis. Adequate NAD+ supports the communication networks that keep your cells functioning as a coordinated system rather than an increasingly disorganized collection of individual units.

Neuroprotection

The brain is one of the most metabolically active organs in the body, and neurons are particularly sensitive to NAD+ depletion. NAD+ supports neuronal energy production, protects against neurodegenerative processes, and supports the synaptic function that underlies memory, learning, and cognitive processing. Declining NAD+ in the brain is associated with age-related cognitive decline and is being studied as a factor in neurodegenerative conditions.

IV NAD+ Administration Protocol

At Rewind Anti-Aging of Miami, NAD+ is administered via intravenous (IV) infusion — the most effective delivery method for achieving rapid, high-concentration cellular replenishment.

Why IV Delivery?

IV administration delivers NAD+ directly into the bloodstream, bypassing the digestive system and achieving 100% bioavailability. Oral NAD+ precursors (NR, NMN) must be absorbed through the gut and converted through multiple enzymatic steps before becoming active NAD+. IV therapy skips these steps entirely, providing immediate, high-dose delivery that oral supplementation cannot match.

Dosing

NAD+ infusion doses typically range from 250 mg to 750 mg per session, depending on the patient's goals, health status, and tolerance:

• 250 mg — a standard dose appropriate for general anti-aging support, energy enhancement, and maintenance
• 500 mg — a mid-range dose commonly used for cognitive optimization, athletic recovery, and patients with moderate NAD+ depletion
• 750 mg — a high dose reserved for intensive protocols including addiction support, severe fatigue, and patients seeking maximum cellular replenishment

Infusion Duration

Each session takes approximately 2 to 4 hours. NAD+ must be infused slowly because rapid administration commonly causes side effects including chest tightness, nausea, and cramping. Our clinical team adjusts the drip rate throughout the session to maximize comfort while delivering the full dose effectively.

Protocol Structure

• Loading phase: 3 to 5 sessions over one to two weeks to rapidly replenish depleted NAD+ stores
• Maintenance phase: Once-monthly infusions to sustain optimal levels
• Intensive protocols: More frequent sessions for specific goals such as addiction recovery or post-illness restoration

Benefits of NAD+ Therapy

• Energy and vitality — improved mitochondrial function translates to sustained daily energy, reduced fatigue, and better stamina
• Cognitive function — better focus, mental clarity, memory, and processing speed. Many patients describe a "brain fog lifting" effect.
• Anti-aging — supporting sirtuins, DNA repair, and cellular resilience at the molecular level addresses aging at its root cause
• Athletic recovery — faster recovery from intense training, reduced muscle soreness, and improved performance capacity
• Addiction support — NAD+ therapy has a history of use in addiction medicine, helping to reduce withdrawal symptoms, cravings, and the neurological damage associated with substance abuse
• Mood and well-being — improved neurotransmitter function and cellular energy support better emotional resilience and overall sense of well-being

Side Effects of NAD+ IV Therapy

Side effects are generally related to the infusion rate and are manageable by slowing the drip:

• Chest tightness or pressure — the most commonly reported sensation. It is not dangerous but can be uncomfortable. Slowing the infusion rate typically resolves it within minutes.
• Nausea — occurs when the infusion is too fast for the patient's tolerance. Managed by reducing the drip rate.
• Abdominal cramping — occasionally reported, typically mild and transient.
• Lightheadedness — rare, and usually related to not eating adequately before the session.
• Flushing or warmth — mild warmth or flushing sensation that resolves as the body processes the NAD+.

These effects are rate-dependent — they are caused by infusing NAD+ faster than the body can comfortably process it. Our clinical team is experienced in finding the optimal drip rate for each patient to minimize discomfort while completing the full dose efficiently.